Rosenfeld Laboratory

  We are investigating the molecular strategies used to generate genome-wide, integrated transcriptional responses to the vast signaling network that regulates development and homeostasis.  We are using genetic, biochemical and biological approaches to define the strategies used by the human body to specify modifications to development and differentiation of cells when genes are expressed. Our work has revealed unexpected gene-specific strategies that link regulated gene responses to other cellular response programs, including DNA damage and DNA repair. Defining these strategies has suggested new approaches to diseases, including growth defects, diabetes, arteriosclerosis, and several prevalent forms of cancer.   

- Geoff Rosenfeld  

   Regulatory Strategies in Development and Function of the Neuroendocrine System 

  Molecular Mechanisms of Regulated Gene Transcription 

  Neural Stem Cells--Corepressor Strategies in Neuronal Development

  Macrophage: Cancer Cell Interactions in Breast and Prostate Cancers

  Sensors and Signals--coactivator and corepressor complexes in genome-wide patterns of gene expression

  Neurodegenerative Diseases

		Immune Cells May Pave the Way for Prostate Cancer (02.10.06)
		Gene Keeps Neural Cells on Correct Developmental Path (05.19.05)
		Explaining Drug Resistance in Prostate Cancer (12.21.03)
		Mice Show How to Calm Anxiety (03.30.00)
		Learning How Organs Tell Left From Right (09.15.99)

M. G. Rosenfeld - Appointments and Awards - Biography

  Investigator, Howard Hughes Medical Institute  
  
  Professor at the University of California, San Diego, School of Medicine  

  Adjunct Professor in the UCSD Division of Biological Sciences   

  Member of the Whitaker Institute of Biomedical Engineering at the UCSD Jacobs School of Engineering   

  Adjunct Professor at The Salk Institute   

  Member of the Moores UCSD Cancer Center     

  Recipient of the Ernst Oppenheimer Young Investigator Award (1983) 
  
  Awarded the McKnight Award, granted by the McKnight Endowment Fund for Neuroscience to gifted, mid-career scientists. (1985)   

  Elected to the American Academy of Arts and Sciences (1991)   

  Elected to the National Academy of Sciences (1994)   

  Recipient of the Fred Conrad Koch Award (1999),  the highest honor of The Endocrine Society  
 
  UCSD Faculty Award for Excellence in Research, by UCSD Health Sciences (2003).

LABORATORY OF M. GEOFFREY ROSENFELD

Investigator, Howard Hughes Medical Institute
Room 345, CMM West, School of Medicine
9500 Gilman Drive, Mail Code 0648
University of California, San Diego
La Jolla, California 92037-0648

Telephone: 858-534-5858
FAX: 858-534-8180

E-mail: mrosenfeld@ucsd.edu

RESEARCH      PUBLICATIONS     LABORATORY RESOURCES     JOIN US